There appear to be rounding errors in many browsers, particularly IE7, when specifying width in em units.
Take the following as an example: two small divs nested inside a larger one. The outer div has a width of 18em. Each inner div has a width of 7em and margins of 1em. Since horizontal margins do not collapse, this layout should fit perfectly flush: (2 * 7em) + (4 * 1em) = 18em.
In certain browsers, at certain font-sizes, the layout breaks: the second inner box falls onto the next line, as if there were not enough space to accommodate it. I’m guessing this is a rounding error of some description.
In this example, at least in my environment, an IE7 rounding error causes the second float to ‘drop’ below the first.